Dr Nigel Kent

BEng PGDip PhD

Lecturer and Director of EngCORE

Carlow Campus

e: nigel.kent@itcarlow.ie      t: 059 9175452


ResearchGate

Dr. Nigel Kent has a B.Eng in Mechatronic Engineering from Dublin City University (DCU). Following his primary degree, he worked in the National Centre for Sensor Research (DCU) as a research engineer involved primarily in the development of chemical sensors for environmental monitoring purposes. Following this role he moved to the Biomedical Diagnostics Institute (DCU) where he undertook his doctoral studies part time in collaboration with the Royal College of Surgeons of Ireland. He has lectured in what was then the Dublin Institute of Technology, Bolton Street primarily in the areas of electronics and control for mechanical engineers. He is currently Director of the IT Carlow Centre of Research and Enterprise for Engineering (engCORE).

 
  • Research Interests
  • Publications
  • Research Supervision
  • Engagement and Collaboration

Research Interests

Dr Kent's research interests lie primarily in the area of chemical and biological sensing with associated instrumentation. From a biological sensing perspective, much of his research has focussed on cardiovascular diseases, developing devices to measure coagulation time, anti platelet drug response and measures of platelet adhesion where the system he developed in conjunction with TU Dublin was successfully trialled in the Clinical Research Centre of Beaumont Hospital. He has also been involved in a breath monitoring diagnostic where his designs have been spun into an commercially successful enterprise. From a chemical sensing perspective the main focus of his work has been the detection of nutrients in marine and fresh water locations both in Ireland and across the globe. Dr Kent was a senior engineer on a team achieving a top eight finish in an autonomous nutrient sensor global competition.

Dr Kent also has an interest in additive manufacturing, primarily in terms of the effect of manufacturing technique on dimensional integrity of a given part.

Publications and Outputs

Patents/Invention Disclosures


Kent N. and Ricco A.J. (2019). Bubble trap for microfluidic devices. IDF filed

Kenny D., Ricco A.J., Somers M., Dunne E., Goldberg E., Bornheimer S. and Kent N. (2018). A Novel Microfluidic Flow Chamber. IDF filed.

Gilmartin N and Kent N. (2016). Cell Detection Bioassay. Priority application filed in the UK 13th December 2016, GB1620447.1.

Nigel J. Kent, Bryan Lincoln, Lourdes Basabe Desmonts, Antonio J. Ricco, Dermot Kenny, Gerardene Meade, Brian G. Corcoran. Microfluidic Device for Assessing Cell Surface Interactions. Pub Number: US 2011/0045993 A1.

Magdalena Maria Dudek, Nigel Kent, Anthony Joseph Killard. An agglutination assay method and device. Pub Number WO2012025637 A9.

Peer Reviewed Journal Articles

Panchal, H., Kent, N., Knox, A., Harris, L. (2020). Microfluidics in haemostasis: a review. Molecules, 25(4), 833. doi:10.3390/molecules25040833

Zhang N; Liu J; Zhang H; Kent NJ; Diamond D; Gilchrist MD. (2019). 3D printing of metallic microstructured mould using selective laser melting for injection moulding of plastic microfluidic devices'. Micromachines (2019) 10 (9)

Colm Delaney, Peter McCluskey, Simon Coleman, Jeffrey Whyte, Nigel Kent and Dermot Diamond. (2017). Precision Control of Flow Rate in Microfluidic Channels Using Photoresponsive Soft Polymer Actuators. Lab on a Chip, 17, 2013 – 2021

Nigel J. Kent, Lina Jolivet, Paul O’Neill and Dermot Brabazon. (2017) An evaluation of components manufactured from a range of materials, fabricated using PolyJet technology Advances in Materials and Processing Technologies.3 (3), 318-329

Paul O’Neill, Lina Jolivet, Nigel J. Kent and Dermot Brabazon. (2017). Physical integrity of 3D printed parts for use as embossing tools. Advances in Materials and Processing Technologies. 3 (3), 308-317

Ralph A, Somers M, Cowman J, Voisin B, Hogan E, Dunne H, Dunne E, Byrne B, Kent N, Ricco AJ, Kenny D, Wong S. (2016). Computational Tracking of Shear-Mediated Platelet Interactions with von Willebrand Factor. Cardiovascular Engineering Technology;7(4):389-405.

Jose B, McCluskey P, Gilmartin N, Somers M, Kenny D, Ricco AJ, Kent NJ, Basabe-Desmonts L. (2016). Self-Powered Microfluidic Device for Rapid Assay of Antiplatelet Drugs. Langmuir. 22;32(11):2820-8. doi: 10.1021/acs.langmuir.5b03540.

Cogan D, Fay C, Boyle D, Osborne C, Kent N, Cleary J, Diamond D. (2015). Development of a low cost microfluidic sensor for the direct determination of nitrate using chromotropic acid in natural waters. Analytical Methods, 7(13), 5396-5405.

Lucitt MB, O’Brien S, Cowman J, Meade G, Basabe-Desmonts L, Somers M, Kent N, Ricco AJ, Kenny D. (2013).  Assaying the efficacy of dual-antiplatelet therapy: use of a controlled-shear-rate microfluidic device with a well-defined collagen surface to track dynamic platelet adhesion. Analytical and Bioanalytical Chemistry, 405, (14), p4823-34.

O’Brien S, Kent NJ, Lucitt M, Ricco AJ, McAtamney C, Kenny D, Meade G. (2012). Effective hydrodynamic shaping of sample streams in a microfluidic parallel-plate flow-assay device: matching whole blood dynamic viscosity. IEEE transactions on bio-medical engineering, 59, (2), p374-82.

Dudek, M. M., Kent, N. J., Fan, Z. H. and Killard A. J. (2011). Development of a fluorescent assay for detecting the onset of coagulation in human plasma on microstructured, lateral flow platforms for point of care devices. Analyst, 136,1816-1825.

Kent, N.J, O’ Brien, S., Basabe-Desmonts, L., Meade, G., MacCraith, B., Corcoran, B., Kenny, D Ricco,A.J,. (2011). Shear Mediated Platelet Adhesion Analysis in Less Than 100 uL of Blood: Towards a POC Platelet Diagnostic. IEEE Transactions Biomedical Engineering :58;826-30

Dudek, M.M., Kent, N.J. Gustafsson, K.M., Lindahl, T. L., Killard A. J. (2011).Fluorescence-based blood coagulation assay device for measuring activated partial thromboplastin time. Analytical Chemistry  Jan 1;83(1):319-28

Kent N.J, Basabe-Desmonts L, Meade GR, Corcoran BG, Kenny D, Ricco AJ. (2010). Microfluidic Device to study shear mediated platelet-surface interactions in whole blood: reduced sample volumes and well-characterized protein surfaces. Biomedical Microdevices  Dec;12(6):987-1000

Lincoln B, Ricco AJ, Kent NJ, Basabe-Desmonts L, Lee LP, MacCraith BD, Kenny D, Meade GR. (2010). Integrated system investigating shear-mediated platelet interactions with von Willebrand factor using microlitre volumes of whole blood. Analytical Biochemistry;405:174-83

Aoife Morrin, Orawan Ngamnac, Eimer O Malley, Nigel Kent, Simon E. Moulton, Gordon G. Wallace, Malcolm R. Smyth, Anthony J. Killard. (2008). The fabrication and characterization of inkjet-printed polyaniline nanoparticle films. Electrochimica Acta 53, 5092 – 5099

Fu-Qiang Nie, Mirek Macka, Leon Barron, Damian Connolly, Nigel Kent and Brett Paull. (2007). Robust monolithic silicabased on-chip electro-osmotic micro-pump. Analyst, 132, 417

William G. Holthoff, Elizabeth C. Tehan, Rachel M. Bukowski, Nigel Kent, Brian D. MacCraith and Frank V. Bright. (2005). Radio luminescent Light Source for the development of Optical Sensor Arrays. Analytical Chemistry, 77,718-72

R. Blue, N. Kent, L. Polerecky, H. McEvoy, D. Gray, and B.D. MacCraith. (2005). Platform for enhanced detection efficiency in luminescence-based sensors. Electronics Letters 9 June Volume 41, Issue 12, p. 682-684

Eadaoin Tyrrell, Ceri Gibson, Brian D. MacCraith, David Gray, Pat Byrne, Nigel Kent, Conor Burke and Brett Paull. (2004). Development of a micro-fluidic manifold for copper monitoring utilising chemiluminescence detection. Lab on a Chip 4(4), 384 – 390

Conference Proceedings/Posters

O’Grady, J., Duffy, G., Maguire, I., Kent, N., Regan, F. Optical enhancement strategies on centrifugal microfluidic water sensors for detection of phosphate. OCEANS, Marseille, June 2019

O’Grady, J., Duffy, G., Maguire, I., Kent, N., Regan, F. Improvements in optical detection in lab-on-a-disc for phosphate sensing. Europtrode Napoli, Italy March 2018

Dunne, E., Schoen, I., Kent, N., Goldberg, E., Bomheimer, S., Ricco, A.J., Kenny, D.J. Intergrating a microfluidic dynamic platelet function assay device with an easy to use video imaging cytometer: validation and preliminary results. Microfluidics for Haematology, Boston USA April 2018

Hall, A.R.; Somers M.; Cowman J., McCluskey, P., Kenny, D., Kent, N. and Gilmartin, N. (2017). Novel biochip detects drug effects in patients with cardiovascular disease in a near patient setting. XXVI ISTH Congress and 63rd Annual Scientific and Standardization Committee (SSC) Meeting, Berlin, Germany July 8-13 2017.

Paul O’Neill, Nigel Kent and Dermot Brabazon. Mitigation of the Overcuring Effect in Mask Projection MicroStereolithography via CAD File Manipulation 20th International ESAFORM Conference on Material Forming 26th – 28th April 2017 Ireland.

Nigel J. Kent, Jinghang Liu and Dermot Brabazon. An Investigation of Dimensional Integrity and Roughness of 3D Printed Photopolymers [KEYNOTE PRESENTATION]. Advances in Materials and Processing Technologies, 8th-11th November 2016, Malaysia.

Nigel J. Kent, Jinghang Liu and Dermot Brabazon. Physical Integrity of 3D printed Parts for use as Embossing Tools. Advances in Materials and Processing Technologies, 8th-11th November 2016, Malaysia.

S. Coleman , A. Ben Azouz , J. ter Schiphorst , J. Saez , J. Whyte, P. McCluskey, N. Kent, F. Benito-Lopez, A. Schenning, and D. Diamond. Next Generation, In-situ Microfluidic Flow Control Using Stimuli Responsive Materials For Biomemetic Microfluidic Platforms. The 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Dublin, 9-13 October 2016.

Hall, A.R., Somers, M., McCluskey, P, Kenny, D., Kent, N. and Gilmartin, N. Towards the automation of a platelet function monitoring biochip for near patient care. 8th Conference on Analytical Science Ireland, Dublin 21st-22nd Apr 2016.

McCluskey, P., Jose, B., Gilmartin, N., Egan K., Lopez-Alonso, A, Basabe-Desmonts L., Kenny, D, Ricco, A.J., Corcoran B., Kent, N. (2014). Self-actuating point of care device for the monitoring of antiplatelet therapies. Biochemical Society Irish Area Section Annual Meeting 2014 & 3rd Irish Platelet Society Biennial Meeting, Dublin 13th-14th Nov 2014.

Whole-Blood Diagnostic Sensing System Based on Populational Platelet Rolling Behavior, A.J. Ricco, N. Kent, G. Meade, B. Lincoln, L. Basabe-Desmonts, B. MacCraith, B. Corcoran, and D. Kenny, ECS Transactions, 19 (6), The Electrochemical Society: Pennington, NJ (2009); pp. 73-77.

Development of a Microfluidic Platform and Detection System for Platelet Function Analysis, N.J. Kent, G. Meade, L. Basabe-Desmonts, B. Lincoln, D. Kenny, A.J. Ricco, B.D. MacCraith, B.G. Corcoran, Proceedings of µTAS 2008 (12th International Conference on Micro Total Analysis Systems), Chemical and Biological Microsystems Society: San Diego (2008); pp. 1048-1050.

Analysis of Whole Blood Platelet Translocation on A vWF-Coated Microfluidic Flow Chamber, B. Lincoln, G. Meade, N. Kent, L. Basabe-Desmonts, D. Kenny, A.J. Ricco, and L.P. Lee, Proceedings of µTAS 2008 (12th International Conference on Micro Total Analysis Systems), Chemical and Biological Microsystems Society: San Diego (2008); pp. 453–455.

Microfluidic System for Whole-Blood Diagnostic Analysis of Populational Platelet Translocation Behavior [INVITED], A.J. Ricco, N. Kent, G. Meade, B. Lincoln, L. Basabe-Desmonts, B. MacCraith, B. Corcoran, and D. Kenny, Gordon Research Conference on Physics & Chemistry of Microfluidics, Il Ciocco, Italy, 6/28-7/3/09/09.

Whole-Blood Diagnostic Sensing System Based on Populational Platelet Rolling Behavior [INVITED], A.J. Ricco, N. Kent, G. Meade, B. Lincoln, L. Basabe-Desmonts, B. MacCraith, B. Corcoran, and D. Kenny, 215th Electrochemical Society National Mtg., San Francisco, 5/24-29/09.

Microfluidic System for Whole-Blood Diagnostic Analysis of Populational Platelet Rolling Behavior [INVITED], A.J. Ricco, N. Kent, G. Meade, B. Lincoln, L. Basabe-Desmonts, B. MacCraith, B. Corcoran, and D. Kenny, 41st Annual Oak Ridge Conference on Point-of-Care Diagnostics, Baltimore, 4/16-17/09.

Microfluidic System for Whole Blood Diagnostic Analysis of Populational Platelet Behavior. N.J. Kent, G. Meade, L. Basabe-Desmonts, D. Kenny, A.J. Ricco, B. MacCraith, B. Corcoran, Lab Automation, Palm Springs, 1/24-27/10.

Blood Volume Is Significantly Reduced In A Novel Parallel Plate Flow Chamber, S. O’Brien, G. Meade, D. Kenny, A. Ricco, N. Kent, ISTH 2009 - XXII Congress of The International Society on Thrombosis and Haemostasis, Boston, 7/11-16/09.

A Novel Analysis Of Initial Platelet-Adhesion In Flowing Blood, G. Meade, S. O’Brien, B. Lincoln, A. Ricco, N. Kent, L. Basabe-Desmonts, L. Lee, B. MacCraith, D. Kenny, ISTH 2009 - XXII Congress of The International Society on Thrombosis and Haemostasis, Boston, 7/11-16/09.

Development of a Microfluidic Platform and Detection System for Platelet Function Analysis, N.J. Kent, G. Meade, L. Basabe-Desmonts, B. Lincoln, D. Kenny, A.J. Ricco, B.D. MacCraith, B.G. Corcoran, µTAS 2008 (12th International Conference on Micro Total Analysis Systems), San Diego, 10/12-16/08.

Analysis of Whole Blood Platelet Translocation on A vWF-Coated Microfluidic Flow Chamber, B. Lincoln, G. Meade, N. Kent, L. Basabe-Desmonts, D. Kenny, A.J. Ricco, and L.P. Lee, µTAS 2008 (12th International Conference on Micro Total Analysis Systems), San Diego, 10/12-16/08.

Development of Hybrid Microfluidic Platform and Detection System for Platelet Function Analysis, N.J. Kent, G. Meade, L. Basabe-Desmonts, B. Lincoln, A.J. Ricco, D. Kenny, B. D. MacCraith, B. Corcoran, Europtrode IX, Dublin, 3/30-4/2/08.

N. J. Kent, B. O’Reilly, B D MacCraith, B Corcoran. Low cost manufacturing technique for hybrid microfluidic platforms. International Manufacturing Conference - Waterford August 2007.

M. Tweedie, R. Subramanian, P.Lemoine, N. Kent, I. Craig, E.T. McAdams, J.A. McLaughlin, B. MacCraith. Fabrication of impedimetric sensors for label-free Point-of-Care immunoassay cardiac marker systems, with passive microfluidic delivery. Proceedings of IEEE 2006.

International Conference of the Engineering in Medicine and Biology Society

McEvoy, Helen M.; Blue, Robert; Kent, Nigel; Polerecky, Lubos; McDonagh, Colette; MacCraith, Brian D. Novel polymer platform for enhanced biochip performance. Proceedings of SPIE-The International Society for Optical Engineering (2005).

Eadaoin Tyrrell, Ceri Gibson, Brian MacCraith, David Gray, Nigel Kent and Brett Paull. Development of a microfluidic based analytical system for copper monitoring in environmental sample matrices. Research and Development Topics, 21-JUL-03 - 23-JUL-03, University of Sunderland.

Eadaoin Tyrrell, Ceri Gibson, Brian MacCraith, Nigel Kent and Brett Paull. Development of a microfluidic based analytical system for copper monitoring in environmental samples. RSC Analytical Research Forum 2004, 19-JUL-04 - 21-JUL-04, University of Central Lancashire, Preston, UK.

Eadaoin Tyrrell, Ceri Gibson, Brian MacCraith, Nigel Kent and Brett Paull.Development of a microfluidic based analytical system for copper monitoring in environmental samples The 7th Asian Conference on Analytical Sciences, 28-JUL-04 - 31-JUL-04, Hong Kong Baptist University, Hong Kong.

Harris, L., Berney, H., O’Riordan, J.J., Kent, N. and Killard, A. J. Development of an impedance-based coagulation assay for monitoring heparin therapy. ICTBSB 2009, 20th-27th January 2009, Dublin City University, Ireland.

Development of Optical Biochip Arrays for Cardiac Markers Cross-Border Programme for Research and Education Contributing to Peace and Reconciliation April 2006. R Blue, N Kent, H McEvoy, S Hearty, R O’Kennedy. B MacCraith

Impedimetric Microfluidic Point of Care Sensors with RF data transmission Cross-Border Programme for Research and Education Contributing to Peace and Reconciliation - Showcase Event June 2005 M. Tweedie, R. Subramanian, I. Craig, E.T. McAdams, J.A. McLaughlin, B. MacCraith, R. O’Kennedy, N. Kent S. Hearty.

Research Supervision

Current

Megan Swan - Microfluidic system to detect bacterial cells causing urinary tract infections. Lead Supervisor (in collaboration with TU Dublin)

Heta Jigar Panchal – Point of Care testing device for antithrombotic monitoring.Co-supervisor (in collaboration with TU Dublin)

Joyce O Grady - Enabling near real-time monitoring of Phosphate in a catchment observation system. Co-supervisor (in collaboration with DCU)

Previous

Peter McCluskey. Development of a microfluidic device and imaging system for the monitoring of anti-platelet therapy. PhD 2015

Stephen Curran. Design and Development of a Low Cost Platform to Facilitate Post-Stroke Rehabilitation of the Elbow/Shoulder Region. M.Eng 2013

Engagement and Collaboration

The engCORE research team collaborate with a number of regional, national and transnational enterprises throughout a range of sectors including: Water & Wastewater treatment, Medical devices, Circuit design, Aviation and Aerospace, Food and Farming, Agri-Tech, Pharmaceutical, Mechanical Design, Sustainable Energy and Manufacturing. These engagements have led to numerous Enterprise Ireland Innovation Partnerships, Commercialisation Fund Technology Development research grants and Irish Research Council Enterprise and Employment based grants being awarded to engCORE and its collaborative partners.

From an engagement perspective Dr. Kent engages with primary and secondary sectors to promote STEM related activities. He has been an active contributor to the VEX robotics primary program within IT Carlow, often visiting schools to promote and assist activities. At second level he has run ‘robotics’ summer camps for junior cycle students. These camps involved the design, build and programming of a line following robot culminating in the final day race off.